4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 18958010, compound

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Reaction Steps

Following the general sulfonylation procedure explained in example 1 but using 5-(2,4-dichlorophenyl)-2-methyl-5-[(1H-1,2,4-triazol-1-yl]methyl)oxazolidine, obtained according to patent ES 334509/91 and 4-trifluoromethylbenzenesulfonyl chloride, the title product is obtained in similar yield as a single isomer. mp 188°-190° C. 1H NMR (80 MHz, CDCl3)δ(TMS) 8.06 (s, 1H, N=CH), 7.80 (s, 1H, N=CH), 7.7-7.2 (m, 5H, arom), 7.02 (s, 2H, arom), 5.20 (q, J=5.3 Hz, 1H, CHMe), 4.60 (AB system, Δv=0.32, J=14.6 Hz, 2H, CH2 -Tr), 4.13 (AB system, Δv=0.62, J=12 Hz, 2H, NCH2), 1.49 (d, J=5.3 Hz, 3H, CHMe). Anal. calcd. for C20H17F3Cl2N4O3S: C 46.08%; H 3.29%; N 10.75%. Found: C 46.34%; H 3.54%; N 10.43%.

Provenance & Evidence