Diisopropylethylamine → HCID 86645384, compound

Participants

Reaction Steps

373 μl (4 mmol) of DIPEA and 385 mg (2.4 mmol) of 2-(thiophen-2-yl)acetyl chloride were added in succession at 0° C. to a solution of 493 mg (2 mmol) of 2-chloro-7-(trifluoromethyl)quinolin-3-amine (VC05) in DCM (14 ml). After stirring for 16 h at RT, the mixture was diluted with DCM. It was then washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo. CC (hexane/EA 19:1) of the residue yielded 321 mg (0.87 mmol, 44%) of N-(2-chloro-7-(trifluoromethyl)quinolin-3-yl)-2-(thiophen-2-yl)acetamide.

Provenance & Evidence