HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 22255Generated: October 28, 2026
Diethyl Ether → 4-Bromomethyl-2-(4-trifluoromethylphenyl)pyrimidine
https://huagongshe.com/reaction/22255
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 4-Methyl-2-(4-trifluoromethylphenyl)pyrimidine | HCID 19430274 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-Bromomethyl-2-(4-trifluoromethylphenyl)pyrimidine | HCID 19430239 | 82.6% |
Reaction Steps
A mixture of 4-methyl-2-(4-trifluoromethylphenyl)pyrimidine (3 g) and bromine (2.11 g) in 20 ml of acetic acid was warmed to 80° C. for 1 hour, and then allowed to cool to room temperature. Ether (10 ml) was added., and the precipitate filtered off and washed with ether, giving 3.3 g of 4-bromomethyl-2-(4-trifluoromethylphenyl)pyrimidine, m.p. 125° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05428037 |
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| Source dataset | uspto-grants-1995_06 |
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| ORD ID | ord-673546b0a9354c379910b70d7eca61f5 |
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| Source note | uspto-grants-1995_06 |
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