Ethanethiol → HCID 67133599, compound

Participants

Reaction Conditions

Reaction Steps

331 mg (2.4 mmol) of K2CO3 and 40 mg (1.6 mmol) of ethanethiol were added to a solution of 300 mg (0.81 mmol) of N-(2-chloro-7-(trifluoromethyl)quinolin-3-yl)-2-(thiophen-2-yl)acetamide in DMF (6 ml), and the mixture was heated for 16 h at 60° C. It was then diluted with water and extracted with EA. The organic phase was washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo. CC (hexane/EA 9:1) of the residue yielded 242 mg (0.6 mmol, 74%) of N-[2-ethylsulfanyl-7-(trifluoromethyl)-quinolin-3-yl]-2-thiophen-2-yl-acetamide. MS: m/z 397.1 [M+H]+.

Provenance & Evidence