Chloride → HCID 178461363, compound

Participants

Reaction Steps

2.7 g of 4-acetoxycinnamic acid derived from p-coumaric acid by the acetylation thereof, 2.8 ml of diethyl chlorophosphate, 3.9 ml of triethylamine, 2 g of trans-4-methylcyclohexylammmonium chloride, 60 ml of methylene chloride, 0.6 g of 4-dimethylaminopyridine, 100 ml of methanol, and 5 g of potassium carbonate, a reaction similar to that conducted in Example 121 was carried out. The product obtained was recrystallized from methylene chloride/hexane, yielding 2.83 g of N-(trans-4-methylcyclohexyl)-4-hydroxycinnamamide (a compound of the present invention) as white crystal, which had the following physiochemical properties:

Provenance & Evidence