Dimethylamine → HCID 178491612, compound

HRID 2225558Notes

Reaction equation

HRID 2225558 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:23])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19]Cl)=[C:13]([O:21][CH3:22])[CH:12]=2)[CH2:4][CH2:3]1.[CH3:24][NH:25][CH3:26]>CC(CC(C)C)=O>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:23])[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:25]([CH3:26])[CH3:24])=[C:13]([O:21][CH3:22])[CH:12]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 178491611HCID 178491611, compound

Product 1

HCID 178491612HCID 178491612, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

Using 1.38 g of N-(trans-4-methylcyclohexyl)-2-[4-(2-chloroethoxy)-3-methoxyphenyl]acetamide (Example 128), 50 ml of methylisobutylketone, and 40 ml of 50% aqueous dimethylamine solution, a reaction similar to that conducted in Example 107 was carried out. As a result, 1.08 g of N-(trans-4-methylcyclohexyl)-2-[4-(2-dimethylaminoethoxy)-3-methoxyphenyl]acetamide (a compound of the present invention) was obtained as pale yellowish white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-29297eed711f449ebb20445facb77ef7
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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