Dimethylamine → HCID 178490523, compound

HRID 2225563Notes

Reaction equation

HRID 2225563 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:27])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]Cl)=[C:14]([O:25][CH3:26])[CH:13]=2)[CH2:4][CH2:3]1.[CH3:28][NH:29][CH3:30]>CC(CC(C)C)=O>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:27])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][N:29]([CH3:30])[CH3:28])=[C:14]([O:25][CH3:26])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 178490519HCID 178490519, compound

Product 1

HCID 178490523HCID 178490523, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

Using 5 g of N-(trans-4-methylcyclohexyl)-4-(5-chloropentyloxy)-3-methoxycinnamamide (Example 132), 100 ml of methylisobutylketone, and 150 ml of 50% aqueous dimethylamine solution, a reaction similar to that conducted in Example 107 was carried out. As a result, 3.17 g of N-(trans-4-methylcyclohexyl)-4-(5-dimethylaminopentyloxy)-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-8c2ff9bc922c407eb66d6ac2b2e0a9fc
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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