Azane;hydrate → HCID 178490533, compound

HRID 2225568Notes

Reaction equation

HRID 2225568 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20]Cl)=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1.O.[NH3:26]>CC(CC(C)C)=O>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][NH2:26])=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 12896473Azane;hydrateHCID 178490530HCID 178490530, compound

Product 1

HCID 178490533HCID 178490533, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Procedure

Using 5 g of N-(trans-4-methylcyclohexyl)-4-(2-chloroethoxy)-3-methoxycinnamamide (Example 138), 100 ml of methylisobutylketone, and 200 ml of 28% ammonia water, a reaction similar to that conducted in Example 107 was carried out. The crystal procipitated was filtered out, yielding 0.9 g of N-(trans-4-methylcyclohexyl)-4-(2-aminoethoxy)-3-methoxycinnamamide (a compound of the present invention) as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to
  2. filtrationThe crystal procipitated was filtered out

Sources & evidence

ORD record
ord-72d2165db9824f41a11986ef65df8234
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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