Aluminium lithium hydride → HCID 59780459, compound

Participants

Reaction Steps

0.50 g (1.64 mmol) of 16, dissolved in 5 ml of THF, was slowly added dropwise to a suspension of 0.12 g (3.27 mmol) of lithium aluminium hydride (LiAlH4, powder) in 10 ml of THF with stirring and ice-cooling. The mixture was stirred for 3 h at RT, excess LiAlH4 was destroyed by addition of saturated ammonium chloride solution, and the mixture was extracted 2× with ethyl acetate. The combined organic phases were dried, the solvent was removed, and the residue was purified by column chromatography (ethyl acetate/cyclohexane), giving a colourless solid (compound 17).

Provenance & Evidence