HCID 178464072, compound → HCID 178464073, compound

HRID 2225575Notes

Reaction equation

HRID 2225575 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:28])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH3:23])=[C:14]([O:26][CH3:27])[CH:13]=2)[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:3][CH2:4][C@H:5]([NH:8][C:9](=[O:28])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25])=[C:14]([O:26][CH3:27])[CH:13]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 178464072HCID 178464072, compound

Product 1

HCID 178464073HCID 178464073, compoundYield 80.3%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 1.5 g of N-(trans-4-methylcyclohexyl)-4-(2-diethylaminoethoxy)-3-methoxycinnamamide (Example 140), 0.075 g of 10% palladium-carbon, and 100 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 1.21 g of N-(trans-4-methylcyclohexyl)-3-[4-(2-diethylaminoethoxy) -3-methoxyphenyl]propionamide (a compound of the present invention) was obtained as a colorless oil, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-7b3fb37e954541eea38ed8a404498841
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

Loading…