HCID 178490412, compound → HCID 178490550, compound

HRID 2225581Notes

Reaction equation

HRID 2225581 reaction equation
C[C@H]1CC[C@H]([C:8](=[CH:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][N:22]([CH3:24])[CH3:23])=[C:15]([O:25][CH3:26])[CH:14]=2)[C:9]([NH2:11])=[O:10])CC1>[C].[Pd].CO>[CH3:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([NH:11][C:9](=[O:10])[CH2:8][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][N:22]([CH3:23])[CH3:24])=[C:15]([O:25][CH3:26])[CH:14]=2)[CH2:15][CH2:14]1

Participants

4

Reactant 1

HCID 178490412HCID 178490412, compound

Product 1

HCID 178490550HCID 178490550, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 2 g of N-(trans-4-methylcyclohexyl-4-(2-dimethylaminoethoxy)-3-methoxycinnamamide (Example 139), 0.1 g of 10% palladium-carbon, and 100 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. The product obtained was recrystallized from methylene chloride/ether, yielding 1.89 g of N-(trans-4-methylcyclohexyl)-3-[4-(2-dimethylaminoethoxy)-3-methoxyphenyl]propionamide (a compound of the present invention) as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to
  2. customThe product obtained
  3. customwas recrystallized from methylene chloride/ether

Sources & evidence

ORD record
ord-9e47a4dfdebb4cc1a0dd885864ef1901
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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