HCID 178446349, compound → HCID 178446350, compound

HRID 2225583Notes

Reaction equation

HRID 2225583 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:34])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[C:14]([O:32][CH3:33])[CH:13]=2)[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:3][CH2:4][C@H:5]([NH:8][C:9](=[O:34])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]([CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[C:14]([O:32][CH3:33])[CH:13]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 178446349HCID 178446349, compound

Product 1

HCID 178446350HCID 178446350, compoundYield 59.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of N-(trans-4-methylcyclohexyl)-4-(2-dipentylaminoethoxy)-3-methoxycinnamamide (Example 159), 0.01 g of 10% palladium-carbon, and 35 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.12 g of N-(trans-4-methylcyclohexyl)-3-[4-(2-dipentylaminoethoxy)-3-methoxyphenyl]propionamide (a compound of the present invention) was obtained was white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-92147149903d4facbd3fe7fed6d40c66
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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