HCID 178490539, compound → HCID 178490540, compound

HRID 2225586Notes

Reaction equation

HRID 2225586 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:35])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[C:14]([O:33][CH3:34])[CH:13]=2)[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:3][CH2:4][C@H:5]([NH:8][C:9](=[O:35])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][CH:24]([N:27]4[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]4)[CH2:23][CH2:22]3)=[C:14]([O:33][CH3:34])[CH:13]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 1

HCID 178490539HCID 178490539, compound

Product 1

HCID 178490540HCID 178490540, compoundYield 59.8%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of N-(trans-4-methylcyclohexyl)-4-[2-(4-piperidinopiperidino)ethoxy]-3-methoxycinnamamide (Example 162), 0.01 g of 10% palladium-carbon, and 30 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.12 g of N-(trans-4-methylcyclohexyl)-3-{4-[2-(4-piperidinopiperidino)ethoxy]-3-methoxyphenyl}propionamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-f9912b5515eb425ebab86c0d2dfbc7cb
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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