Methyl Isobutyl Ketone → HCID 178462640, compound

HRID 2225587Notes

Reaction equation

HRID 2225587 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20]Cl)=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1.C([C:27]1[NH:28][CH:29]=[CH:30][N:31]=1)C.[CH3:32][C:33](CC(C)C)=O>>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:24])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][C:27]3[N:31]([CH2:32][CH3:33])[CH:30]=[CH:29][N:28]=3)=[C:14]([O:22][CH3:23])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 7909Methyl Isobutyl KetoneHCID 661302-EthylimidazoleHCID 178490530HCID 178490530, compound

Product 1

HCID 178462640HCID 178462640, compound

Procedure

Using 1.9 g N-(trans-4-methylcyclohexyl)-4-(2-chloroethoxy)-3-methoxycinnamamide (Example 138), 2.7 g 2-ethylimdazole, and 50 ml of methylisobutyketone, a reaction similar to that conducted in Example 142 was carried out. As a result, 1.78 g of N-(trans-4-methylcyclohexyl)-4-{2-[1-(2-ethyl)imidazolyl]ethoxy}-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-ec110d661607450b852535f66cf444bc
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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