HCID 178490411, compound → HCID 178490542, compound

HRID 2225589Notes

Reaction equation

HRID 2225589 reaction equation
C[C@H]1CC[C@H]([C:8](=[CH:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][N:22]3[C:26]4C=CC=C[C:25]=4[N:24]=[CH:23]3)=[C:15]([O:31][CH3:32])[CH:14]=2)[C:9]([NH2:11])=[O:10])CC1>[C].[Pd].CO>[CH3:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([NH:11][C:9](=[O:10])[CH2:8][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][N:22]3[CH:26]=[CH:25][N:24]=[CH:23]3)=[C:15]([O:31][CH3:32])[CH:14]=2)[CH2:15][CH2:14]1

Participants

4

Reactant 1

HCID 178490411HCID 178490411, compound

Product 1

HCID 178490542HCID 178490542, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of N-(trans-4-methylcyclohexyl-4-[2-[1-benzimidazolyl)ethoxy]-3-methoxycinnamamide Example 166), 0.01 g of 10% palladium-carbon, and 35 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.11 g of N-(trans-4-methylcyclohexyl)-3-{4-[2-(1-imidazolyl)ethoxy}-3-methoxyphenyl}propionamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-d0320fea06d8477a984f829cb3b1310e
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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