Potassium Hydroxide → 3-(3-Methoxyphenyl)prop-2-enamide

HRID 2225592Notes

Reaction equation

HRID 2225592 reaction equation
C[C@H]1CC[C@H]([NH:8][C:9](=[O:27])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15](OCC(OCC)=O)=[C:14]([O:25][CH3:26])[CH:13]=2)CC1.[OH-].[K+]>CO>[CH3:26][O:25][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[CH:11]=[CH:10][C:9]([NH2:8])=[O:27]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178472972HCID 178472972, compound

Product 1

HCID 572965063-(3-Methoxyphenyl)prop-2-enamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using 28 g of N-(trans-4-methylcyclohexyl )-4-(ethoxycarbonylmethoxy) -3-methoxycinnamamide (Example 171), 100 ml of 254 aqueous potassium hydroxide solution, and 600 ml of methanol, a reaction similar to that conducted in Example 169 was carried out. As a result, 23.9 g of N-(trans-4-methylcyclohexyl )-4-carboxymethoxy)-3-methoxycinnamamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-d8480bee4df44ae9bf431061794e8e60
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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