HCID 178490520, compound → HCID 178490521, compound

HRID 2225598Notes

Reaction equation

HRID 2225598 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:29])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[C:14]([O:27][CH3:28])[CH:13]=2)[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:29])[CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[C:14]([O:27][CH3:28])[CH:13]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 178490520HCID 178490520, compound

Product 1

HCID 178490521HCID 178490521, compoundYield 69.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of N-(trans-4-methylcyclohexyl )-4-(5-carboxypentyloxy) -3-methoxycinnamamide, 0.01 g of 10% palladium-carbon, and 35 mR of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.14 g of N-(trans-4methylcyclohexyl) -3-[4-(5-carboxypentyloxy )- 3methoxyphenyl]propionamide (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-af9a4d0b4d2e464abec2cc5e87b4c48a
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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