HCID 178490556, compound → HCID 178490557, compound

HRID 2225603Notes

Reaction equation

HRID 2225603 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([CH:11]=[CH:12][C:13]2[CH:29]=[CH:28][C:16]([O:17][CH2:18][C:19]([N:21]3[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]3)=[O:20])=[C:15]([O:30][CH3:31])[CH:14]=2)=[O:10])[CH2:4][CH2:3]1>[C].[Pd].CO>[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([CH2:11][CH2:12][C:13]2[CH:29]=[CH:28][C:16]([O:17][CH2:18][C:19]([N:21]3[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]3)=[O:20])=[C:15]([O:30][CH3:31])[CH:14]=2)=[O:10])[CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 178490556HCID 178490556, compound

Product 1

HCID 178490557HCID 178490557, compoundYield 64.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Using 0.2 g of 1-{4-{2-[N-(trans-4-methylcyclohexyl) carbamoyl]vinyl}-2-methoxyphenoxyacetyl}-4-methylpiperazine (Example 188 ), 0.01 g of 10% palladium-carbon, and 30 ml of methanol, a reaction similar to that conducted in Example 147 was carried out. As a result, 0.13 g of 1-{4-{2-[N-(trans-4-methylcyclohexyl) carbamoyl]ethyl}-2methoxyphenoxyacetyl}-4-methylpiperazine (a compound of the present invention) was obtained as white crystal, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-be969580d8ab43a795711c6b051669eb
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

Loading…