2-Methoxythiophene → HCID 19004463, compound

Participants

Reaction Steps

As in Example 1, a solution of 2-methoxythiophene (11.4 g) and 2-(cyclooctyloxy) ethanol (13.78 g) in benzene (200 mL) containing para-toluenesulfonic acid (0.1 g) was stirred at reflux for 3 days in a flask equipped with a Soxhlet extractor charged with 4 Å molecular sieves. After the reaction was worked up in the usual manner, the crude product was purified by HPLC (hexane-diethyl ether; 2.4: 1) to give 12.6 g of 2-[[2-(cyclooctyloxy) ethyl]oxy]thiophene as a colorless oil. A small portion was distilled in a Kugelrohr apparatus (~130 ° C./0.02 mm) to furnish the analytical specimen.

Provenance & Evidence