Potassium Hydroxide → HCID 19004363, compound

HRID 2225626Notes

Reaction equation

HRID 2225626 reaction equation
[OH-].[K+].C([O:5][C:6](=[O:26])[C:7](=[O:25])[C:8]1[S:9][C:10]([O:13][CH2:14][CH2:15][O:16][CH:17]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:11][CH:12]=1)C>CO>[CH:17]1([O:16][CH2:15][CH2:14][O:13][C:10]2[S:9][C:8]([C:7](=[O:25])[C:6]([OH:26])=[O:5])=[CH:12][CH:11]=2)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 53795195HCID 53795195, compound

Product 1

HCID 19004363HCID 19004363, compoundYield 95.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1N Potassium hydroxide solution (10 mL) was added dropwise with stirring to a chilled solution of 5-[[2-(cyclooctyloxy)ethyl]oxy]-alpha-oxo-2-thiopheneacetic acid ethyl ester (4.43 g) in methanol (50 mL). After the reaction was stirred at 0°-5° C. for 15 minutes, the product was isolated as described in Example 6 to furnish 3.9 g of 5-[[2-(cyclooctyloxy)ethyl]oxy]-alpha-oxo-2-thiopheneacetic acid as a yellow-orange oil. Crystallization of the product from wet benzene-hexane furnished 3.1 g of the hydrated acid as a pale yellow crystalline solid, mp 60°-62 ° C.

Workup

  1. customthe product was isolated

Sources & evidence

ORD record
ord-ae02d606d7ed4f06bed11b8856039716
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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