Sodium Hydroxide → HCID 19004457, compound

Participants

Reaction Steps

A mixture of 4-[(phenylmethyl)oxy]-alpha-oxobenzeneacetic acid methyl ester (0.53 g) in methanol (5 mL) and 0. SN sodium hydroxide (8 mL) were heated on the steam bath for 0.5 hours while methanol was distilled out. The resulting mixture containing solid sodium salt was cooled, concentrated to remove the organic solvents, acidified with 1N hydrochloric acid (4 mL), and extracted with diethyl ether (3×25 mL). The organic layers were washed in turn with water (2×10 mL) and the combined organic layers were dried (Na2SO4), filtered, and evaporated to give 0.5 g of crude product. Crystallization from benzene-hexane provided 0.45 g of 4-[(phenylmethyl)oxy]-alpha-oxobenzeneacetic acid, mp 97°-98° C.

Provenance & Evidence