Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzenebutanol | HCID 76889 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | Benzeneacetic acid, 4-hydroxy-alpha-oxo-, methyl ester | HCID 3084696 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 54511840 | HCID 54511840 | 51% |
Reaction Steps
A stirred mixture of 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester (0.724 g) in dimethylformamide (10 mL) under argon was treated with 55% sodium hydride (0.175 g), stirred for 15 minutes and treated with the mesylate of 4-phenylbutanol (1.37 g). The mixture was heated at 60° C. overnight and worked up as in Example 20. The material was purified by HPLC (dichloromethane-hexane; 2:1) to provide 0.64 g of 4-[(4-phenybutyl)oxy]-alpha-oxobenzeneacetic acid methyl ester as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05344843 |
|---|
| Source dataset | uspto-grants-1994_09 |
|---|
| ORD ID | ord-e6fccd6632e14de194af2358f2880a82 |
|---|
| Source note | uspto-grants-1994_09 |
|---|
