HCID 54330803, compound → HCID 19004447, compound

HRID 2225643Notes

Reaction equation

HRID 2225643 reaction equation
C[O:2][C:3](=[O:22])[C:4](=[O:21])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]#[C:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[O:21]=[C:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]#[C:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:7][CH:6]=1)[C:3]([OH:22])=[O:2]

Participants

4

Reactant 1

HCID 54330803HCID 54330803, compound

Product 1

HCID 19004447HCID 19004447, compoundYield 82.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of alpha-oxo-4-[(3-phenyl-2-propynyl)oxy]benzeneacetic acid methyl ester (0.7 g) in methanol (10 mL) and 0.SN sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided solids which were crystallized from diethyl ether-hexane to give 0.55 g of colorless alpha-oxo-4-[(3-phenyl-2-propynyl)oxy]benzeneacetic acid, mp 97°-99° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided solids which
  4. customwere crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-f58fc2b5345a48229d7fa61af8cc3ece
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

Loading…