HCID 53850434, compound → HCID 19004409, compound

HRID 2225647Notes

Reaction equation

HRID 2225647 reaction equation
C[O:2][C:3](=[O:23])[C:4](=[O:22])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][CH2:13][CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([C:4](=[O:22])[C:3]([OH:23])=[O:2])=[CH:10][CH:9]=1

Participants

4

Reactant 1

HCID 53850434HCID 53850434, compound

Product 1

HCID 19004409HCID 19004409, compoundYield 95.9%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[[2-(2-fiuorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.6 g) in methanol (20 mL) and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided solids which were crystallized from diethyl ether-hexane to give 0.55 g of colorless 4-[[2-(2-fluorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 108°-110° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided solids which
  4. customwere crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-e4482143d83d471db0026b064389855f
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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