HCID 54216543, compound → HCID 19004541, compound

HRID 2225649Notes

Reaction equation

HRID 2225649 reaction equation
C[O:2][C:3](=[O:23])[C:4](=[O:22])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[F:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[O:14][CH2:13][CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([C:4](=[O:22])[C:3]([OH:23])=[O:2])=[CH:10][CH:9]=1

Participants

4

Reactant 1

HCID 54216543HCID 54216543, compound

Product 1

HCID 19004541HCID 19004541, compoundYield 84.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[[2-(3-fluorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.62 g) in methanol (5 mL) and 0.5N sodium hydroxide (6 mL) was treated as in Example 19. Extraction provided solids which were crystallized from diethyl ether-hexane to give 0.5 g of colorless 4-[[2-(3-fluorophenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 108°-109° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided solids which
  4. customwere crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-e3df801aea0243c8ba4f44e264829ad7
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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