HCID 57095388, compound → HCID 21744666, compound

HRID 2225660Notes

Reaction equation

HRID 2225660 reaction equation
C[O:2][C:3](=[O:28])[C:4](=[O:27])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:21](=[O:26])[C:22]([O:24]C)=[O:23]>CO.[OH-].[Na+]>[CH2:12]([O:11][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[C:4](=[O:27])[C:3]([OH:28])=[O:2])[CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[C:21](=[O:26])[C:22]([OH:24])=[O:23]

Participants

4

Reactant 1

HCID 57095388HCID 57095388, compound

Product 1

HCID 21744666HCID 21744666, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4,4'-[1,2-ethanediylbis(oxy)bis(alpha-oxobenzeneacetic acid) dimethyl ester (4:1) molar hydrate (0.385 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction with tetrahydrofuran provided solids where were crystallized from acetonitrile to give 0.315 g of colorless 4,4'-[1,2-ethanediylbis(oxy) bis(alpha-oxobenzene-acetic acid) acid as an 0.25 molar hydrate, mp 212°-213° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction with tetrahydrofuran provided solids where
  3. customwere crystallized from acetonitrile

Sources & evidence

ORD record
ord-4e9eadac49014241843a5b4660cdbf82
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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