HCID 54129750, compound → HCID 19004278, compound

HRID 2225664Notes

Reaction equation

HRID 2225664 reaction equation
C[O:2][C:3](=[O:24])[C:4](=[O:23])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[CH3:22][O:21][C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:13][CH2:12][O:11][C:8]2[CH:9]=[CH:10][C:5]([C:4](=[O:23])[C:3]([OH:24])=[O:2])=[CH:6][CH:7]=2)=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 54129750HCID 54129750, compound

Product 1

HCID 19004278HCID 19004278, compoundYield 88.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[[2-(4-methoxyphenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.77 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction with dichloromethane provided material which solidified and was crystallized from diethyl ether-hexane to give 0.65 g of colorless 4-[[2-(4-methoxyphenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 138°-139° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction with dichloromethane provided material which
  3. customwas crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-821e4abb92a24d09b1ce6cc280c8aed7
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

Loading…