Hydrochloric Acid → HCID 19004269, compound

Participants

Reaction Steps

A mixture of 4-[[2-(3,4,5-trimethoxyphenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.9 g) in methanol and 0.5N sodium hydroxide (8 mL) was heated on the steam bath for 0.5 hours, chilled, and 2N hydrochloric acid (5 mL) added. The resulting solids were filtered, washed with water and then boiled in benzene to dry. Filtration, evaporation and crystallization from diethyl ether-hexane provided 0.625 g of colorless 4-[[2-(3,4,5-trimethoxyphenoxy)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 118°-119° C.

Provenance & Evidence