HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2225669Generated: October 26, 2026
Sodium hydride → alpha-Oxo-4-[[(phenoxy)methyl]oxy]benzeneacetic acid methyl ester
https://huagongshe.com/reaction/2225669
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (Chloromethoxy)benzene | HCID 81201 | — |
| Reactant | Benzeneacetic acid, 4-hydroxy-alpha-oxo-, methyl ester | HCID 3084696 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | alpha-Oxo-4-[[(phenoxy)methyl]oxy]benzeneacetic acid methyl ester | HCID 54321081 | 62.9% |
Reaction Steps
A stirred mixture of 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester (1.0 g) in dimethylformamide (10 mL) under argon was treated with 55% sodium hydride (0.262 g), stirred for 15 minutes and treated with chloromethoxybenzene (1.1 g). The mixture was heated at 60° C. for 1.5 hours and worked up as in Example 20. The material was crystallized from diethyl ether-hexane to provide 1 g of alpha-oxo-4-[[(phenoxy)methyl]oxy]benzeneacetic acid methyl ester, mp 52°-54° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05344843 |
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| Source dataset | uspto-grants-1994_09 |
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| ORD ID | ord-2807e102fe724b8499622eb18aa8f504 |
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| Source note | uspto-grants-1994_09 |
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