alpha-Oxo-4-[[(4phenoxy)butyl]oxy]benzeneacetic acid methyl ester → alpha-Oxo-4-[[(4-phenoxy)butyl]oxy]benzeneacetic acid

HRID 2225674Notes

Reaction equation

HRID 2225674 reaction equation
C[O:2][C:3](=[O:24])[C:4](=[O:23])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[O:23]=[C:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:7][CH:6]=1)[C:3]([OH:24])=[O:2]

Participants

4

Reactant 1

HCID 54438110alpha-Oxo-4-[[(4phenoxy)butyl]oxy]benzeneacetic acid methyl ester

Product 1

HCID 19004285alpha-Oxo-4-[[(4-phenoxy)butyl]oxy]benzeneacetic acidYield 86%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of alpha-oxo-4-[[(4-phenoxy)butyl]oxy]benzeneacetic acid methyl ester (0.85 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided material which was crystallized from diethyl ether-hexane to give 0.7 g of colorless alpha-oxo-4-[[(4-phenoxy)butyl]oxy]benzeneacetic acid, mp 103°-105° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided material which
  4. customwas crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-2dfea69a2c9a4fca9e2642a9ce6b5e27
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

Loading…