HCID 54457781, compound → HCID 19004379, compound

HRID 2225679Notes

Reaction equation

HRID 2225679 reaction equation
C[O:2][C:3](=[O:25])[C:4](=[O:24])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[O:17]([CH2:16][CH2:15][O:14][CH2:13][CH2:12][O:11][C:8]1[CH:7]=[CH:6][C:5]([C:4](=[O:24])[C:3]([OH:25])=[O:2])=[CH:10][CH:9]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 1

HCID 54457781HCID 54457781, compound

Product 1

HCID 19004379HCID 19004379, compoundYield 89.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[[2-[[2-(phenoxy)ethyl]oxy]ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.7 g) in methanol and 0.5N sodium hydroxide (8 mL) was treated as in Example 19. Extraction provided solids which were crystallized from benzene-hexane to give 0.6 g of colorless 4-[[2-[[2-(phenoxy)ethyl]oxy]ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 58°-59° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction
  3. customprovided solids which
  4. customwere crystallized from benzene-hexane

Sources & evidence

ORD record
ord-8ba942d2fb5a469ab195d6b3f28822ae
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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