Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Benzeneacetic acid, 4-hydroxy-alpha-oxo-, methyl ester | HCID 3084696 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 53978224 | HCID 53978224 | — |
Reaction Steps
A stirred mixture of 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester (2.71 g) in dimethylformamide (20 mL) under argon was treated with 55% sodium hydride (0.65 g) , stirred for 15 minutes and treated with epichlorohydrin (12 mL). The mixture was heated at 60° C. for four hours and worked up as in Example 20. The material was purified by HPLC (dichloromethane-diethyl ether; 50:1) to provide 2.4 g of 4-(oxiranylmethoxy)alpha-oxobenzeneacetic acid methyl ester, as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05344843 |
|---|
| Source dataset | uspto-grants-1994_09 |
|---|
| ORD ID | ord-9c2d4de02f1e474596907008864b0dbc |
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| Source note | uspto-grants-1994_09 |
|---|
