Sodium Hydroxide → HCID 67756817, compound

HRID 2225686Notes

Reaction equation

HRID 2225686 reaction equation
C[O:2][C:3](=[O:26])[C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=2)=[CH:7][CH:6]=1.[OH-].[Na+:28]>C(O)C>[Na+:28].[CH:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:23]=[CH:24][C:15]=1[O:14][CH2:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:4](=[O:25])[C:3]([O-:26])=[O:2])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 541704664-[2-(2-Naphthalenyloxy)ethoxy]-alpha-oxobenzeneacetic acid methyl ester

Product 1

HCID 67756817HCID 67756817, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-[[2-(2-naphthalenyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (3.2 g) in 95% ethanol (700 mL) was heated at reflux and 1N sodium hydroxide (15 mL) was added dropwise. Heating was continued for five minutes and the resulting mixture was chilled in ice, filtered, washed with water and dried at 80° C. over phosphorus pentoxide at 0.1 mm to give 3.2 g of colorless 4-[[2-(2-naphthalenyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid sodium salt, mp>295° C. with decomposition.

Workup

  1. temperaturewas heated
  2. temperatureat reflux
  3. temperatureHeating
  4. temperaturethe resulting mixture was chilled in ice
  5. filtrationfiltered
  6. washwashed with water
  7. dry with materialdried at 80° C. over phosphorus pentoxide at 0.1 mm

Sources & evidence

ORD record
ord-6feaa93e83d74bbd8ec91af2cf708abb
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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