HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[[4-(2Naphthalenyloxy) butyl]oxy]-alpha-oxobenzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[[4-(2-Naphthalenyloxy)butyl]oxy]-alpha-oxobenzeneacetic acid methyl ester | HCID 53794298 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[[4-(2Naphthalenyloxy) butyl]oxy]-alpha-oxobenzeneacetic acid | HCID 19004381 | 49.6% |
Reaction Steps
A mixture of 4-[[4-(2-naphthalenyloxy)butyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.9 g) in methanol (15 mL), acetone (5 mL), and 0.5N sodium hydroxide (10 mL) was treated as in Example 19. Extraction with dichloromethane provided material which was crystallized from diethyl ether-hexane to give 0.43 g of colorless 4-[[4-(2naphthalenyloxy) butyl]oxy]-alpha-oxobenzeneacetic acid, mp 133°-135°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05344843 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-9a81f7aec5924c83841231684e68156f |
| Source note | uspto-grants-1994_09 |