HCID 54560109, compound → HCID 19004373, compound

HRID 2225691Notes

Reaction equation

HRID 2225691 reaction equation
C[O:2][C:3](=[O:26])[C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][S:14][C:15]2[CH:24]=[CH:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[CH:16]1[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:23]=[CH:24][C:15]=1[S:14][CH2:13][CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([C:4](=[O:25])[C:3]([OH:26])=[O:2])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 54560109HCID 54560109, compound

Product 1

HCID 19004373HCID 19004373, compoundYield 84%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[[2-(2-naphthalenylthio)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.495 g) in methanol and 0.5N sodium hydroxide (5 mL) was treated as in Example 19. Extraction with dichloromethane provided material which was crystallized from diethyl ether-hexane to give 0.4 g of colorless 4-[[2-(2-naphthalenylthio)ethyl]oxy]-alpha-oxobenzeneacetic acid, mp 121°-123° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction with dichloromethane provided material which
  3. customwas crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-6b2e16aa3fde44fcb70a8a5354d30e19
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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