HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester → 4-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[[2-(Cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester | HCID 54321041 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 4-[[2-(Cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid | HCID 19004352 | 89.8% |
Reaction Steps
A mixture of 4-[[2-(cyclohexyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.7 g) in methanol (10 mL) and 0.5N sodium hydroxide (7 mL) was treated as in Example 19. Extraction with diethyl ether provided material which was crystallized from diethyl ether-hexane to give 0.6 g of colorless 4-[[2-(cyclohexyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid, mp 96°-98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05344843 |
| Source dataset | uspto-grants-1994_09 |
| ORD ID | ord-90b957c3af2c469c9d3603aee62c589e |
| Source note | uspto-grants-1994_09 |