HCID 53858000, compound → HCID 19004429, compound

HRID 2225702Notes

Reaction equation

HRID 2225702 reaction equation
C[O:2][C:3](=[O:24])[C:4](=[O:23])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[CH:7][CH:6]=1>CO.[OH-].[Na+]>[CH:15]1([O:14][CH2:13][CH2:12][O:11][C:8]2[CH:7]=[CH:6][C:5]([C:4](=[O:23])[C:3]([OH:24])=[O:2])=[CH:10][CH:9]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 1

HCID 53858000HCID 53858000, compound

Product 1

HCID 19004429HCID 19004429, compoundYield 76.5%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 4-[[2-(cyclooctyloxy)ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.3 g) in methanol (10 mL) and 0.5N sodium hydroxide (4 mL) was treated as in Example 19. Extraction with dichloromethane provided material which was crystallized from diethyl ether-hexane to give 0.22 g of colorless 4-[[2-(cyclooctyloxy)ethyl]oxy]-alphaoxobenzeneacetic acid, mp 64°-65° C.

Workup

  1. additionwas treated as in Example 19
  2. extractionExtraction with dichloromethane provided material which
  3. customwas crystallized from diethyl ether-hexane

Sources & evidence

ORD record
ord-c44c2b226a17404ebd518eac420d73eb
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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