HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2225723Generated: November 1, 2026
Triphenylphosphine → alpha-Oxo-4-[4-(3-pyridinyl)butoxy]benzeneacetic acid methyl ester
https://huagongshe.com/reaction/2225723
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | Benzeneacetic acid, 4-hydroxy-alpha-oxo-, methyl ester | HCID 3084696 | — |
| Reactant | 3-Pyridinebutanol | HCID 13419136 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | alpha-Oxo-4-[4-(3-pyridinyl)butoxy]benzeneacetic acid methyl ester | HCID 53999955 | 70.6% |
Reaction Steps
A stirred mixture of 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester (1.14 g), 3-pyridinebutanol (1.04 g), triphenylphosphine (2.07 g), and tetrahydrofuran (25 mL) was stirred at 0° C. while adding dropwise a solution of diethyl azodicarboxylate (1.37 g) in tetrahydrofuran (10 mL). The mixture was stirred for 2 hours at 0° C. and evaporated to dryness. The material was purified by HPLC (hexane-acetone; 2:1) to provide 1.4 g of alpha-oxo-4-[4-(3-pyridinyl)butoxy]benzeneacetic acid methyl ester (4:1) molar hydrate as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05344843 |
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| Source dataset | uspto-grants-1994_09 |
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| ORD ID | ord-c638c51050244ca5a59c36e99b3171d4 |
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| Source note | uspto-grants-1994_09 |
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