反应详情

A mixture of alpha-oxo-4-[4-(4-pyridinyl)butoxy]benzeneacetic acid methyl ester (0.58 g) in hot methanol (10 mL) was treated with 1N sodium hydroxide (3.0 mL) and diluted with water. The organic solvent was removed under vacuum and the residue in water was washed with diethyl ether. The aqueous layer was concentrated to about 25 mL and chilled in ice. Cold 2N hydrochloric acid (1.5 mL) was added dropwise and the product was allowed to crystallize and was filtered and air dried. Recrystallization from water provided 0.55 g of alpha-oxo-4-[4-(4-pyridinyl)butoxy]benzeneacetic acid as a colorless solid, mp 198°-199° C.

1. customThe organic solvent was removed under vacuum
2. washthe residue in water was washed with diethyl ether
3. concentrationThe aqueous layer was concentrated to about 25 mL
4. temperaturechilled in ice
5. additionCold 2N hydrochloric acid (1.5 mL) was added dropwise
6. customto crystallize
7. filtrationwas filtered
8. customair dried
9. customRecrystallization from water