Sodium Hydroxide → HCID 19004320, compound

Participants

Reaction Steps

A mixture of alpha-oxo-4-[[2-(4-quinolyloxy)ethyl]oxy]benzeneacetic acid methyl ester (0.50 g) in hot methanol (10 mL) was treated with 1N sodium hydroxide (4.0 mL) and diluted with water. The organic solvent was removed under vacuum and the residue was dissolved in water and chilled in ice. Cold 2N hydrochloric acid (2.0 mL) was added dropwise and the product was allowed to crystallize and was filtered, washed with water and dried to give 0.477 g of alpha-oxo-4-[[2-(4-quinolyloxy)ethyl]oxy]benzeneacetic acid as a colorless solid, mp 271° C. with decomposition.

Provenance & Evidence