Hydrochloric Acid → HCID 19004370, compound

Participants

Reaction Steps

To a solution of 4-[[2-[8-(2,2-dimethyl-1 -oxobutoxy)-2-naphthalenyloxy]ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.3 g) in methanol (7 mL) was added aqueous 1N sodium hydroxide (1.35 mL). After 15 minutes, the reaction was acidified with 1N hydrochloric acid (2 mL) and extracted with dichloromethane. The organic layer was washed with brine and evaporated to provide 4-[[2-[8-(2,2-dimethyl-1-oxobutoxy)-2naphthalenyloxy]ethyl]oxy]-alpha-oxobenzeneacetic acid as a white solid, mp 167°-168° C.

Provenance & Evidence