Hydrochloric Acid → HCID 19004273, compound

Participants

Reaction Steps

To a solution of 4-[[2-[2-[(2,2-dimethyl-1 -oxobuyloxy)methyl]-6-methylphenoxy]ethyl]oxy]-alpha-oxobenzeneacetic acid methyl ester (0.554 g) in methanol (10 mL) was added aqueous 1N sodium hydroxide (2.5 mL). After 30 minutes at 50° C., the reaction was acidified with 1N hydrochloric acid (2 mL) and extracted with dichloromethane. The organic phase was washed with brine and evaporated to provide 0.47 g of 4-[[2-[2-[(2,2-dimethyl-1-oxobuyloxy) methyl]-6-methylphenoxy]ethyl]oxy]-alpha-oxobenzeneacetic acid (2:1) hydrate as a clear oil.

Provenance & Evidence