Methyl chloroformate → HCID 54465876, compound

Participants

Reaction Steps

A solution of crude 4-[[2-(2-naphthalenyloxy)ethyl]thio]-alpha-oxobenzeneacetic acid (1.6 g) in dichloromethane (500 mL) and triethylamine (1 mL) was treated with methyl chloroformate (0.58 mL) and stirred at room temperature for 1 hour. The mixture was diluted with water, extracted with dichloromethane, dried (Na2SO4), filtered and evaporated. The material from dichloromethane extraction was purified by HPLC (dichloromethane-hexane; 2:1) and crystallized from dichloromethane-diethyl ether to provide 0.85 g of 4-[[2-(2-naphthalenyloxy)ethyl]thio]-alpha-oxobenzeneacetic acid methyl ester, mp 124°-125° C.

Provenance & Evidence