Potassium Hydroxide → HCID 19004277, compound

Participants

Reaction Steps

As in Example 19, (E)-4-[3-[4'-fluoro-3-(1-methylethyl)[1,1'-biphenyl]-2-yl]-2-propenyloxy]-alpha-oxobenzeneacetic acid methyl ester (0.5 g) in a mixture of methanol (4 mL) and tetrahydrofuran (2 mL) was treated with 1N potassium hydroxide (1.4 mL). The usual work up gave 0.4 g of a solid, which after crystallization from diethyl ether-hexane provided 0.3 g of (E)-4-[3-[4'-fluoro-3-(1-methylethyl)[1,1'-biphenyl]-2-yl]-2-propenyloxy]-alpha-oxobenzeneacetic acid as a colorless solid, mp 142°-143° C.

Provenance & Evidence