反应详情

To a solution of 4'-fluoro-3-(1-methylethyl)[1,1'-biphenyl]-2-ol formate (2 g) in ethanol (5 mL) was added a 10% solution of potassium hydroxide in ethanol (10 mL) and the reaction mixture was stirred at room temperature for 1 hour. The reaction was concentrated in vacuo, and the residue was partitioned between dichloromethane (20 mL) and 1N hydrochloric acid (20 mL). The separated aqueous layer was extracted with dichloromethane (2×20 mL), then the combined organic layers were washed with water, dried (MgSO4) and evaporated to furnish 1.9 g of 4'-fluoro-3-(1-methylethyl) [1,1'-biphenyl]-2-ol as a oil which solidified on standing. A small sample was sublimed to give the analytical specimen, mp 41°-43° C.

1. concentrationThe reaction was concentrated in vacuo
2. customthe residue was partitioned between dichloromethane (20 mL) and 1N hydrochloric acid (20 mL)
3. extractionThe separated aqueous layer was extracted with dichloromethane (2×20 mL)
4. washthe combined organic layers were washed with water
5. dry with materialdried (MgSO4)
6. customevaporated