Sodium Hydroxide → HCID 19004483, compound

Participants

Reaction Steps

As in Example 19, (E)-4-[3-[4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl]-2propenyloxy]-alpha-oxobenzeneacetic acid methyl ester (0.84 g) in a mixture of methanol (10 mL) and tetrahydrofuran (1.5 mL) was treated with 1N sodium hydroxide (1.9 mL). The usual work up furnished 0.82 g of a solid, which was crystallized from ethyl acetate to yield 0.63 g of (E)-4-[3-[4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolin]-2-propenyloxy]-alpha-oxobenzeneacetic acid, mp 232°-234° C.

Provenance & Evidence