Diethyl Ether → HCID 58111159, compound

Participants

Reaction Steps

To a solution of 2-fluoro-1-{4-[4-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenoxymethyl]-piperidin-1-yl}-2-methyl-propan-1-one (1.00 g, 2.28 mmol) in tetrahydrofuran (23 mL) at rt is added via cannula a 1 M solution of lithium aluminum hydride in tetrahydrofuran (7.18 g, 7.98 mL, 7.98 mmol). After 1 h, sodium sulfate decahydrate is added carefully. The mixture is stirred for 15 min and the solid is filtered off and washed with dichloromethane. The solvent is removed and the residue is purified via silica gel chromatography, eluting with dichloromethane:ethyl acetate 5.6:1 to 2:1 to obtain a solid. Diethyl ether is added and the solid is filtered and washed with diethyl ether and ethyl acetate to obtain 0.245 g of the title compound as a white solid. MS (m/z) 425 (M+1).

Provenance & Evidence