Water → HCID 19004319, compound

HRID 2225815Notes

Reaction equation

HRID 2225815 reaction equation
[Br:1][CH2:2][C:3](Cl)=[O:4].[F:6][C:7]([F:23])([F:22])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.O>ClCCl>[Br:1][CH2:2][C:3]([N:19]1[CH2:18][CH2:17][N:16]([CH2:15][CH2:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7]([F:22])([F:23])[F:6])[CH2:21][CH2:20]1)=[O:4]

Participants

5

Reactant 3

HCID 962WaterHCID 89602Bromoacetyl chlorideHCID 30233251-[2-(trifluoromethyl)phenethyl]piperazine

Product 1

HCID 19004319HCID 19004319, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Bromoacetyl chloride (0.125 mL) was added slowly to a chilled (5 ° C.) solution of 1-[2-[2-(trifluoromethyl)phenyl]ethyl]piperazine (0.774 g) in dichloromethane (20 mL) and the mixture was stirred in an ice bath for 45 minutes, then at room temperature for 18 hours. After the addition of water (20 mL), the organic layer was separated and washed in turn with 0.5N hydrochloric acid and sodium bicarbonate solution. The dried (MgSO4) extract was evaporated to give 0.5 g of 1-(2-bromo-1-oxoethyl)-4-[2-[2-(trifluoromethyl)phenyl]ethyl]piperazine.

Workup

  1. waitat room temperature for 18 hours
  2. customthe organic layer was separated
  3. washwashed in turn with 0.5N hydrochloric acid and sodium bicarbonate solution
  4. dry with materialThe dried (MgSO4)
  5. extractionextract
  6. customwas evaporated

Sources & evidence

ORD record
ord-e122b200a7934759ba9a1ebb41fb5c15
Source dataset
uspto-grants-1994_09
Patent number
US05344843

Reaction notes

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