Sodium Hydroxide → HCID 19004365, compound

Participants

Reaction Steps

As in example 10, a solution of 4-[5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-5-oxopentyloxy]-alpha-oxobenzeneacetic acid ethyl ester (0.8 g) in hot methanol (80 mL) was treated with 2N sodium hydroxide (1.75 mL) was stirred at room temperature for 75 minutes. The methanol was removed in vacuo, then the mixture was acidified with 3N hydrochloric acid and extracted with dichloromethane-tetrahydrofuran (2:1). The dried (MgSO4) extracts were evaporated and the solid residue was triturated from hexane, and then crystallized from acetone-hexane to provide 0.7 g of 4-[5-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-5-oxopentyloxy]-alpha-oxobenzeneacetic acid, mp 144°-145° C.

Provenance & Evidence