Water → HCID 19004460, compound

Participants

Reaction Steps

As in example 19, a stirred solution of 4-(2-cyclooctyl-2-oxoethoxy)-alpha-oxobenzeneacetic acid ethyl ester (0.318 g) in warm methanol (5 mL) was treated with 1N sodium hydroxide (2 mL). Within 5 minutes water (20 mL) was added, then after the methanol was removed in vacuo, the mixture was acidified with 1N hydrochloric acid (2.5 mL) and extracted with dichloromethane (1×40 mL, 1×10 mL). The dried (MgSO4) extracts were evaporated and the resulting solid (0.255 g) was crystallized from diethyl ether-hexane to give 0.178 g of 4-[2-(cyclooctyl)-2-oxoethoxy]-alpha-oxobenzeneacetic acid as a colorless solid, mp 109°-110° C.

Provenance & Evidence